Research Grant

Institution:

University of Cambridge

Recipient:

Prof. Ken Siddle

Project:

Mechanism of action of Grb10, a negative regulator of insulin signalling & a potential drug target for treating Type 2 diabetes

Summary:

Professor Ken Siddle and his team are studying a group of proteins (Grbs) which seem able to blunt the action of insulin by binding directly to the insulin receptor protein and inhibiting the signals the receptor would normally send to regulate a cell's metabolism.
There is some evidence that these Grb proteins are more abundant in tissues of diabetics, and they might contribute to the "insulin resistance" that characterises the diabetic state.
If we understand more about the way Grbs work we might be able to target them with drugs to improve insulin sensitivity.

Amount:

£29,662