Research Grant

Institution:

University of Edinburgh

Recipient:

Dr Neeraj Dhuan

Project:

Endothelin receptor antagonism as a therapeutic target in diabetic nephropathy

Summary:

Diabetes is the most common cause of kidney failure in the developed world. Patients with diabetic kidney disease have higher blood pressures and lower blood flow to the kidneys than the general population. They also have stiffer blood vessels and more heart disease.

The presence of protein in the urine suggests deteriorating kidney function and an increased risk of heart disease. If we are to tackle diabetic kidney disease effectively not only do we need to manage the problems with kidney function but also the heart disease with which they are associated.

In this research, we wish to build on previous work that looked at a chemical produced by blood vessels called endothelin. Using endothelin blocking strategies we hope to show whether we can reduce blood pressure and blood vessel stiffness, increase blood flow to the kidneys, and decrease the amount of protein in the urine of individuals with diabetic kidney disease.

If encouraging, these experiments may lead to future treatments that slow the progression of diabetic kidney disease and reduce the associated heart problems.

Amount:

£29,061