Open Funding

Institution:

University of Birmingham

Recipient:

Dr Parth Narendran

Project:

Does Adiponectin influence the loss of T-Cell tolerance and the development of Type 1 diabetes?

Summary:

Type 1 diabetes is caused by the body’s own immune system attacking the insulin producing cells in the pancreas. Patients do not appear to be able to regulate their immune system, and this is thought to contribute to developing type 1 diabetes. The reasons for this poor regulation are not clear. We and others have previously shown that features associated with being overweight are also associated with the development of type 1 diabetes. We would now like to determine whether these features affect the regulation of the immune system and ultimately the development of type 1 diabetes. This is an important study because understanding the relationship between body weight and the immune system can help develop strategies such as weight loss, including drugs aimed at reducing obesity, to prevent type 1 diabetes.

Amount:

£29,400